Safe fetal platelet genotyping: new developments
Identifieur interne : 000498 ( Main/Exploration ); précédent : 000497; suivant : 000499Safe fetal platelet genotyping: new developments
Auteurs : Emilie Le Toriellec [France] ; Christophe Chenet [France] ; Cecile Kaplan [France]Source :
- Transfusion [ 0041-1132 ] ; 2013-08.
Abstract
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is due to maternal alloimmunization against fetal platelet (PLT) antigens. Antenatal management strategies have been developed to avoid complications such as intracranial hemorrhage. The aim of this study was to set up two reliable, noninvasive fetal genotyping assays to determine the fetal risk in pregnancies in which the father is heterozygous for the offending antigen. This study focused on human PLT antigen (HPA)‐1, the most frequently implicated antigen in FNAIT in Caucasians.
Url:
DOI: 10.1111/j.1537-2995.2012.03954.x
Affiliations:
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